Hypnotics and Anxiolytics: Part 6.

The next medication would be buspirone. Buspirone is prescribed for short management of anxiety. Commonly, buspirone is given to patients with generalized anxiety disorder.

MOA: Buspirone targets mostly serotonin receptors to exert its anxiolytic activity. However, it also shows moderate affinity for dopamine receptors. Buspirone produces minimal sedation.

ADR:

• Headaches.
• Dizziness.
• Nervousness.
• Light-headedness.
• Excitement.
• Paraesthesia.
• Sleep disturbances.
• Chest pain.
• Tinnitus.

TU:

• Mild to severe anxiety.

PRCTN:

• Pregnant and lactating mothers.
• Epileptic patients.
• Renal or hepatic impairment.

Note: Buspirone is much preferred compared to Biodiazepines among elderly patients because it does not interfere with motor functions.